Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | CDC26 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | 9kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CDC26 AA range: 21-71 |
| Specificity | This antibody detects endogenous levels of CDC26 at Human/Mouse/Rat |
| Gene Name | CDC26 ANAPC12 C9orf17 |
| Protein Name | CDC26 |
| Other Name | |
| Species | Human |
| Gene ID | 246184 |
| Uniprot | Q8NHZ8, |
| Species.1 | Mouse |
| Gene ID.1 | 66440 |
| Uniprot.1 | Q99JP4, |
| Species.2 | Rat |
| Gene ID.2 | 366381 |
| Uniprot.2 | Q6YDN7 |
| Cellular Localization | Nucleus . |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cell cycle |
| Research Areas | >>Cell cycle; / >>Oocyte meiosis; / >>Ubiquitin mediated proteolysis; / >>Progesterone-mediated oocyte maturation; / >>Human T-cell leukemia virus 1 infection |
| Function | Function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase that controls progression through mitosis and the G1 phase of the cell cycle. May recruit the E2 ubiquitin-conjugating enzymes to the complex.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CDC26 family.,subunit:The APC/C is composed of at least 11 subunits., |
