Price range: $268.00 through $328.00
Background:
This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | CdGAP |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 157kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from CdGAP . at AA range: 730-810 |
| Specificity | CdGAP Polyclonal Antibody detects endogenous levels of CdGAP protein. |
| Gene Name | ARHGAP31 |
| Protein Name | Rho GTPase-activating protein 31 |
| Other Name | ARHGAP31; / CDGAP; / KIAA1204; / Rho GTPase-activating protein 31; / Cdc42 GTPase-activating protein |
| Species | Human |
| Gene ID | 57514 |
| Uniprot | Q9ULL6 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytosol,focal adhesion,lamellipodium, |
| Tissue Expression | Brain, |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Mainly expressed in fetal heart and muscle.,Function:Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration.,PTM:Phosphorylation on Thr-789 reduces GAP activity.,similarity:Contains 1 Rho-GAP domain.,subunit:Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA., |
