CDHF10 Polyclonal Antibody
Ucallm_WP11553-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CDHF10 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 317kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CELSR2. AA range:2781-2830 |
| Specificity | CDHF10 Polyclonal Antibody detects endogenous levels of CDHF10 protein. |
| Gene Name | CELSR2 |
| Protein Name | Cadherin EGF LAG seven-pass G-type receptor 2 |
| Other Name | CELSR2; / CDHF10; / EGFL2; / KIAA0279; / MEGF3; / Cadherin EGF LAG seven-pass G-type receptor 2; / Cadherin family member 10; / Epidermal growth factor-like protein 2; / EGF-like protein 2; / Flamingo homolog 3; / Multiple epidermal growth factor-like domains |
| Species | Human |
| Gene ID | 1952 |
| Uniprot | Q9HCU4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9R0M0, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9QYP2 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Highest expression in brain and testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Receptor that may have an important role in cell/cell signaling during nervous system formation.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 laminin EGF-like domain.,similarity:Contains 2 laminin G-like domains.,similarity:Contains 7 EGF-like domains.,similarity:Contains 9 cadherin domains.,tissue specificity:Highest expression in brain and testis., |
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