Price range: $268.00 through $328.00
Background:
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012],
| Target | CDX2 |
| Reactivity | Human, Monkey |
| Applications | WB, IP, ICC |
| MW(Calculated) | |
| MW(Observed) | 34kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:1000; ICC 1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 5D10 |
| Immunogen | Purified recombinant human CDX2 protein fragments expressed in E.coli. |
| Sequence | |
| Specificity | This antibody detects endogenous levels of CDX2 and does not cross-react with related proteins. |
| Gene Name | cdx2 |
| Protein Name | |
| Other Name | Caudal type homeo box 2; / Caudal type homeo box transcription factor 2; / Caudal type homeobox 2; / Caudal type homeobox protein 2; / caudal type homeobox transcription factor 2; / Caudal-type homeobox protein 2; / CDX 2; / CDX 3; / CDX-3; / Cdx2; / CDX2_HUMAN; / CDX3; / Homeobox protein CDX 2; / Homeobox protein CDX-2; / Homeobox protein CDX2. |
| Species | Human |
| Gene ID-1 | 1045 |
| Uniprot | Q99626, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | P43241 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012], |
| Cellular Localization | Nucleus . |
| Tissue Expression | Detected in small intestine, colon and pancreas. |
| Signaling_pathway | Human Diseases >> Cancer: specific types >> Gastric cancer |
| Research Areas | >>Gastric cancer |
| Function | Function:Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.,PTM:Phosphorylation of Ser-60 mediates the transactivation capacity.,similarity:Belongs to the Caudal homeobox family.,similarity:Contains 1 homeobox DNA-binding domain., |
| RRID |
