SKU: WP16482 Categories: ,

CE120 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16482-100
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Product details

Background:

This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

Specifications

Size50μL/100μL
TargetCE120
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)108kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human CE120 AA range: 335-385
SpecificityThis antibody detects endogenous levels of CE120 at Human/Mouse
Gene NameCEP120 CCDC100
Protein NameCE120
Other Name
SpeciesHuman
Gene ID153241
UniprotQ8N960,
Species.1Mouse
Gene ID.1225523
Uniprot.1Q7TSG1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm, cytoskeleton, microtubule organizing center, centrosome . Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo. .
Tissue Expression
Signaling_pathway
Research Areas
FunctionFunction:Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors.,similarity:Belongs to the CEP120 family.,subcellular location:Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo.,subunit:Interacts with TACC2 and TACC3.,
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