CENPC Polyclonal Antibody
Ucallm_WP0730-50
Price range: $268.00 through $328.00
Product details
Background:
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CENPC |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 103kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 160-240 |
| Specificity | CENPC Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CENPC1 CENPC ICEN7 |
| Protein Name | Centromere protein C 1 (CENP-C 1) (Centromere autoantigen C) (Interphase centromere complex protein 7) |
| Other Name | |
| Species | Human |
| Gene ID | 1060 |
| Uniprot | Q03188, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P49452 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Chromosome, centromere, kinetochore . Chromosome, centromere . Localizes exclusively in the kinetochore domain of centromeres. . |
| Tissue Expression | Blood,Epithelium,Placenta,Testis, |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Antibodies against CENPC are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.,Function:Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.,subcellular location:Localizes exclusively in the kinetochore domain of centromeres.,subunit:Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX., |
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