Price range: $268.00 through $328.00
Background:
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
| Size | 50μL/100μL |
| Target | cGKII |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 87kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CGK 2. AA range:391-440 |
| Specificity | cGKII Polyclonal Antibody detects endogenous levels of cGKII protein. |
| Gene Name | PRKG2 |
| Protein Name | cGMP-dependent protein kinase 2 |
| Other Name | PRKG2; / PRKGR2; / cGMP-dependent protein kinase 2; / cGK 2; / cGK2; / cGMP-dependent protein kinase II; / cGKII |
| Species | Human |
| Gene ID | 5593 |
| Uniprot | Q13237, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61410, |
| Species.2 | Rat |
| Gene ID.2 | 25523 |
| Uniprot.2 | Q64595 |
| Cellular Localization | Apical cell membrane; Lipid-anchor . |
| Tissue Expression | Highly concentrated in brain, lung and intestinal mucosa. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Organismal Systems >> Immune system >> Platelet activation;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | >>cGMP-PKG signaling pathway; / >>Gap junction; / >>Platelet activation; / >>Circadian entrainment; / >>Thermogenesis; / >>Long-term depression; / >>Olfactory transduction; / >>Regulation of lipolysis in adipocytes; / >>Renin secretion; / >>Salivary secretion |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Binding of cGMP results in enzyme activation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 cyclic nucleotide-binding domains.,tissue specificity:Highly concentrated in brain, lung and intestinal mucosa., |
