Product details
Background:
function:Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis., PTM:Phosphorylated on serine and tyrosine residues., sequence caution:Wrong choice of frame., similarity:Belongs to the SNF2/RAD54 helicase family., similarity:Contains 1 helicase ATP-binding domain., similarity:Contains 1 helicase C-terminal domain., similarity:Contains 2 chromo domains., subunit:Interacts with PPARA. Probably interacts with ESR1 and NR1I3., tissue specificity:Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts.,
