Price range: $268.00 through $328.00
Background:
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009],
| Size | 50μL/100μL |
| Target | CHRDL1 |
| Reactivity | Human |
| Applications | WB, IHC, ICC |
| MW(Calculated) | |
| MW(Observed) | 52kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; IHC 1:300; ICC 1:300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 19E2 |
| Immunogen | Purified recombinant human CHRDL1 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of CHRDL1 and does not cross-react with related proteins. |
| Gene Name | chrdl1 |
| Protein Name | Chordin-like protein 1 |
| Other Name | CHL; / chordin like 1; / Chordin-like protein 1; / CHRDL1; / CRDL1_HUMAN; / dA141H5.1; / neuralin 1; / Neuralin-1; / Neurogenesin-1; / NRLN1; / Ventroptin; / VOPT. |
| Species | Human |
| Gene ID | 91851 |
| Uniprot | Q9BU40 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . |
| Tissue Expression | Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.,induction:By hypoxia in retinal pericytes.,similarity:Contains 3 VWFC domains.,tissue specificity:Expressed in retinal pericytes., |
