SKU: WM1358 Categories: ,

Chromogranin A [PTR1330] mouse mAb

Price range: $268.00 through $328.00

SKU: WM1358-50
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Product details

Background:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],

Specifications

Size50μL/100μL
TargetChromogranin A
ReactivityHuman, Mouse, Rat
ApplicationsIHC, WB, IF, ELISA
MW(Calculated)51kD
MW(Observed)70kD
Host SpeciesMouse
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMMR1330
ImmunogenSynthesized peptide derived from human Chromogranin A AA range: 19-94
SpecificityThis antibody detects endogenous levels of Chromogranin A protein.
Gene NameCHGA
Protein Namebeta Granin; betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; CHG A; Chga; chromofungin; Chromogranin A; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; CMGA_HUMAN; ER-37; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; Secretory protein I; SP I; SP-I; SP1; SPI; vasostatin 2; Vasostatin; Vasostatin I; Vasostatin II; vasostatin-2
Other Namebeta Granin antibody; / betagranin; / N-terminal fragment of chromogranin A; / antibody; / catestatin antibody; / CgA antibody; / CHG A antibody; / Chga antibody; / chromofungin antibody; / Chromogranin A antibody; / Chromogranin A parathyroid secretory protein 1 antibody; / Chromogranin A precursor antibody; / ChromograninA antibody; / CMGA_HUMAN antibody; / ER-37 antibody; / Pancreastatin antibody; / Parastatin antibody; / Parathyroid secretory protein 1 antibody; / Pituitary secretory protein I antibody; / Secretory protein I antibody; / SP I antibody; / SP-I antibody; / SP1 antibody; / SPI antibody; / vasostatin 2 antibody; / Vasostatin antibody; / Vasostatin I antibody; / Vasostatin II antibody; / vasostatin-2 antibody
SpeciesHuman
Gene ID1113
UniprotP10645,
Species.1Mouse
Gene ID.112652
Uniprot.1P26339,
Species.2Rat
Gene ID.2
Uniprot.2P10354
Cellular LocalizationCytoplasmic
Tissue ExpressionPancreas/ stomach
Signaling_pathway
Research Areas
FunctionFunction:Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.,miscellaneous:Binds calcium with a low-affinity.,PTM:Sulfated on tyrosine residues and/or contains sulfated glycans.,similarity:Belongs to the chromogranin/secretogranin protein family.,subcellular location:Neuroendocrine and endocrine secretory granules.,
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