Chromogranin A [PTR1330] mouse mAb
Ucallm_WM1358-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],
Specifications
| Size | 50μL/100μL |
| Target | Chromogranin A |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 51kD |
| MW(Observed) | 70kD |
| Host Species | Mouse |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR1330 |
| Immunogen | Synthesized peptide derived from human Chromogranin A AA range: 19-94 |
| Specificity | This antibody detects endogenous levels of Chromogranin A protein. |
| Gene Name | CHGA |
| Protein Name | beta Granin; betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; CHG A; Chga; chromofungin; Chromogranin A; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; CMGA_HUMAN; ER-37; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; Secretory protein I; SP I; SP-I; SP1; SPI; vasostatin 2; Vasostatin; Vasostatin I; Vasostatin II; vasostatin-2 |
| Other Name | beta Granin antibody; / betagranin; / N-terminal fragment of chromogranin A; / antibody; / catestatin antibody; / CgA antibody; / CHG A antibody; / Chga antibody; / chromofungin antibody; / Chromogranin A antibody; / Chromogranin A parathyroid secretory protein 1 antibody; / Chromogranin A precursor antibody; / ChromograninA antibody; / CMGA_HUMAN antibody; / ER-37 antibody; / Pancreastatin antibody; / Parastatin antibody; / Parathyroid secretory protein 1 antibody; / Pituitary secretory protein I antibody; / Secretory protein I antibody; / SP I antibody; / SP-I antibody; / SP1 antibody; / SPI antibody; / vasostatin 2 antibody; / Vasostatin antibody; / Vasostatin I antibody; / Vasostatin II antibody; / vasostatin-2 antibody |
| Species | Human |
| Gene ID | 1113 |
| Uniprot | P10645, |
| Species.1 | Mouse |
| Gene ID.1 | 12652 |
| Uniprot.1 | P26339, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P10354 |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Pancreas/ stomach |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.,miscellaneous:Binds calcium with a low-affinity.,PTM:Sulfated on tyrosine residues and/or contains sulfated glycans.,similarity:Belongs to the chromogranin/secretogranin protein family.,subcellular location:Neuroendocrine and endocrine secretory granules., |
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