CHST9 Polyclonal Antibody
Ucallm_WP11630-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011],
Specifications
| Size | 50μL/100μL |
| Target | CHST9 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 51kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHST9. AA range:361-410 |
| Specificity | CHST9 Polyclonal Antibody detects endogenous levels of CHST9 protein. |
| Gene Name | CHST9 |
| Protein Name | Carbohydrate sulfotransferase 9 |
| Other Name | CHST9; / Carbohydrate sulfotransferase 9; / GalNAc-4-O-sulfotransferase 2; / GalNAc-4-ST2; / GalNAc4ST-2; / N-acetylgalactosamine-4-O-sulfotransferase 2 |
| Species | Human |
| Gene ID | 83539 |
| Uniprot | Q7L1S5, |
| Species.1 | Mouse |
| Gene ID.1 | 71367 |
| Uniprot.1 | Q76EC5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Golgi apparatus membrane; Single-pass type II membrane protein .; [Isoform 2]: Secreted . |
| Tissue Expression | Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord. |
| Signaling_pathway | |
| Research Areas | >>Various types of N-glycan biosynthesis; / >>Metabolic pathways |
| Function | Caution:It is uncertain whether Met-1 or Met-8 is the initiator.,Function:Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.,similarity:Belongs to the sulfotransferase 2 family.,tissue specificity:Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord., |
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