Product details
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CHTF18 rabbit pAb
Ucallm_WP8352-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | CHTF18 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 107kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CHTF18 |
| Specificity | This antibody detects endogenous levels of CHTF18 at Human, Mouse |
| Gene Name | CHTF18 C16orf41 CTF18 |
| Protein Name | Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) |
| Other Name | |
| Species | Human |
| Gene ID | 63922 |
| Uniprot | Q8WVB6, |
| Species.1 | Mouse |
| Gene ID.1 | 214901 |
| Uniprot.1 | Q8BIW9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Associates with chromatin during S phase. |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage . |
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