Product details
Background:
- Please choose product options by visiting CISD2 Polyclonal Antibody.
- Please choose product options by visiting CISD1 rabbit pAb.
CIAO1 rabbit pAb
Ucallm_WP7928-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | CIAO1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 37kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CIAO1 |
| Specificity | This antibody detects endogenous levels of CIAO1 at Human, Mouse,Rat |
| Gene Name | CIAO1 WDR39 |
| Protein Name | Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39) |
| Other Name | |
| Species | Human |
| Gene ID | 9391 |
| Uniprot | O76071, |
| Species.1 | Mouse |
| Gene ID.1 | 26371 |
| Uniprot.1 | Q99KN2, |
| Species.2 | Rat |
| Gene ID.2 | 29231 |
| Uniprot.2 | Q5M7T1 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins . As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 . Seems to specifically modulate the transactivation activity of WT1 . As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation . |
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