U-Blot® cIAP2 Rabbit mAb
Ucallm_WR4680-50
Price range: $268.00 through $328.00
Product details
Background:This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011],
Specifications
| Size | 50μL/100μL |
| Target | cIAP2 |
| Reactivity | Human |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 68kD |
| MW(Observed) | 68kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0954R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | BIRC3 |
| Protein Name | Baculoviral IAP repeat-containing protein 3 |
| Other Name | AIP 1; / AIP1; / API 2; / API2; / API2; / Apoptosis inhibitor 2; / Baculoviral IAP repeat containing 3; / Baculoviral IAP repeat containing protein 3; / Baculoviral IAP repeat-containing protein 3; / BIRC 3; / BIRC3; / BIRC3; / BIRC3_HUMAN; / C IAP2; / C-IAP2; / CIAP 2; / CIAP 2; / CIAP2; / HAIP 1; / HAIP1; / HAIP1; / HIAP 1; / HIAP-1; / HIAP1; / IAP homolog C; / IAP-1; / Inhibitor of apoptosis protein 1; / Inhibitor of apoptosis protein 1; / MALT 2; / MALT2; / Mammalian IAP homolog C; / MIHC; / MIHC; / RING finger protein 49; / RNF49; / TNFR2 TRAF signaling complex protein 1; / TNFR2 TRAF signalling complex protein; / TNFR2-TRAF-signaling complex protein 1. |
| Species | Human |
| Gene ID | 330 |
| Uniprot | Q13489, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O08863 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Apoptosis;Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Cellular Processes >> Cell growth and death >> Necroptosis;Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Small cell lung cancer;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis |
| Research Areas | >>Platinum drug resistance; / >>NF-kappa B signaling pathway; / >>Ubiquitin mediated proteolysis; / >>Apoptosis; / >>Apoptosis - multiple species; / >>Necroptosis; / >>Hippo signaling pathway; / >>Focal adhesion; / >>NOD-like receptor signaling pathway; / >>TNF signaling pathway; / >>Salmonella infection; / >>Toxoplasmosis; / >>Herpes simplex virus 1 infection; / >>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Small cell lung cancer |
| Function | Disease:A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11; 18)(q21; q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,Function:Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).,similarity:Belongs to the IAP family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.,tissue specificity:Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes., |
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