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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/CIB1 Monoclonal Antibody
SKU: WM0118 Categories: ,

CIB1 Monoclonal Antibody

Ucallm_WM0118-50

Price range: $268.00 through $328.00

SKU: WM0118-50
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Product details

Background:
This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013],

Specifications

Size50μL/100μL
TargetCIB1
ReactivityHuman
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)22kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number1E12
ImmunogenPurified recombinant fragment of CIB1 expressed in E. Coli.
SpecificityCIB1 Monoclonal Antibody detects endogenous levels of CIB1 protein.
Gene NameCIB1 CIB KIP PRKDCIP
Protein NameCalcium and integrin-binding protein 1
Other NameCIB1; / CIB; / KIP; / PRKDCIP; / Calcium and integrin-binding protein 1; / CIB; / Calcium- and integrin-binding protein; / CIBP; / Calmyrin; / DNA-PKcs-interacting protein; / Kinase-interacting protein; / KIP; / SNK-interacting protein 2-28; / SIP2-28
SpeciesHuman
Gene ID10519
UniprotQ99828
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Lipid-anchor. Cell membrane, sarcolemma. Cell membrane. Apical cell membrane. Cell projection, ruffle membrane. Cell projection, filopodium tip. Cell projection, growth cone . Cell projection, lamellipodium . Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Nucleus . Cell projection, neuron projection . Perikaryon . Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with PLK3 at centrosomes in ductal breast carcinoma cells. .; [Isoform 2]: Cytoplasm, perinuclear region . Golgi apparatus, trans-Golgi network .
Tissue ExpressionUbiquitously expressed. Expressed in the epidermis, hair follicles and keratinocytes (PubMed:30068544). Detected in platelets and in cell lines of megakaryocytic and erythrocytic lineages. Both isoform 1 and isoform 2 are detected in various cancer cell lines, with isoform 2 being the predominant form (at protein level).
Signaling_pathway
Research Areas
FunctionFunction:May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through the binding to the integrin cytoplasmic domain.,similarity:Contains 2 EF-hand domains.,subunit:Monomer. Interacts with the heterodimeric integrin alpha-IIb/beta3. Interacts with the protein kinases PLK2/SNK and with the region immediately upstream of the kinase domain of DNA-PK. Interacts with PSEN2. Interacts with MYO1C.,tissue specificity:Ubiquitous.,
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