SKU: WM1220 Categories: ,

Claudin-2 Mouse Monoclonal Antibody [8H11]

Price range: $268.00 through $328.00

SKU: WM1220-50
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Product details

Background:
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],

Specifications

Size50μL/100μL
TargetClaudin-2
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, IHC
MW(Calculated)
MW(Observed)25kD
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IF/ICC1:200-400; IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityMonoclonal
Clone Number8H11
ImmunogenSynthesized peptide derived from human Claudin-2
SpecificityThis antibody detects endogenous levels of human Claudin-2
Gene NameCLDN2 PSEC0059 SP82 UNQ705/PRO1356
Protein NameClaudin-2
Other NameClaudin-2; / SP82
SpeciesHuman
Gene ID9075
UniprotP57739
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell junction, tight junction . Cell membrane; Multi-pass membrane protein .
Tissue ExpressionColon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,
Signaling_pathwayCellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas>>Cell adhesion molecules; / >>Tight junction; / >>Leukocyte transendothelial migration; / >>Pathogenic Escherichia coli infection; / >>Hepatitis C
FunctionFunction:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
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