Claudin-2 Mouse Monoclonal Antibody [8H11]
Ucallm_WM1220-50
Price range: $268.00 through $328.00
Product details
Background:
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],
Specifications
| Size | 50μL/100μL |
| Target | Claudin-2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, IHC |
| MW(Calculated) | |
| MW(Observed) | 25kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF/ICC1:200-400; IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Monoclonal |
| Clone Number | 8H11 |
| Immunogen | Synthesized peptide derived from human Claudin-2 |
| Specificity | This antibody detects endogenous levels of human Claudin-2 |
| Gene Name | CLDN2 PSEC0059 SP82 UNQ705/PRO1356 |
| Protein Name | Claudin-2 |
| Other Name | Claudin-2; / SP82 |
| Species | Human |
| Gene ID | 9075 |
| Uniprot | P57739 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell junction, tight junction . Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus, |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules; / >>Tight junction; / >>Leukocyte transendothelial migration; / >>Pathogenic Escherichia coli infection; / >>Hepatitis C |
| Function | Function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3., |
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