Claudin 3 [ABT509] mouse mAb
Ucallm_WM1516-50
Price range: $268.00 through $328.00
Product details
Background:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Claudin 3 |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 23kD |
| MW(Observed) | 22kD |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM509 |
| Immunogen | Synthesized peptide derived from human Claudin 3 AA range: 150-220 |
| Specificity | The antibody can specifically recognize human Claudin 3 protein. |
| Gene Name | CLDN3 C7orf1 CPETR2 |
| Protein Name | C7orf1; Claudin-3; Claudin3; CLD3_HUMAN; CLDN 3; Cldn3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; CPE-R 2; CPE-receptor 2; CPETR 2; CPETR2; HRVP 1; HRVP1; Rat ventral prostate 1 like protein; Rat ventral prostate.1 protein homolog; RVP1; Ventral prostate.1 like protein; Ventral prostate.1 protein homolog |
| Other Name | C7orf1; / Claudin-3; / Claudin3; / CLD3_HUMAN; / CLDN 3; / Cldn3; / Clostridium perfringens enterotoxin receptor 2; / CPE R2; / CPE receptor 2; / CPE-R 2; / CPE-receptor 2; / CPETR 2; / CPETR2; / HRVP 1; / HRVP1; / Rat ventral prostate 1 like protein; / Rat ventral prostate.1 protein homolog; / RVP1; / Ventral prostate.1 like protein; / Ventral prostate.1 protein homolog |
| Species | Human |
| Gene ID | 1365 |
| Uniprot | O15551, |
| Species.1 | Mouse |
| Gene ID.1 | 12739 |
| Uniprot.1 | Q9Z0G9, |
| Species.2 | Rat |
| Gene ID.2 | 65130 |
| Uniprot.2 | Q63400 |
| Cellular Localization | Membranous |
| Tissue Expression | Colon/ Appendix |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules; / >>Tight junction; / >>Leukocyte transendothelial migration; / >>Pathogenic Escherichia coli infection; / >>Hepatitis C |
| Function | Disease:Haploinsufficiency of CLDN3 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,Function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3., |
Please login to post questions
Related products
