CLIP3 Polyclonal Antibody
Ucallm_WP11675-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010],
Specifications
| Size | 50μL/100μL |
| Target | CLIP3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CLIP3. AA range:361-410 |
| Specificity | CLIP3 Polyclonal Antibody detects endogenous levels of CLIP3 protein. |
| Gene Name | CLIP3 |
| Protein Name | CAP-Gly domain-containing linker protein 3 |
| Other Name | CLIP3; / CLIPR59; / CAP-Gly domain-containing linker protein 3; / Cytoplasmic linker protein 170-related 59 kDa protein; / CLIP-170-related 59 kDa protein; / CLIPR-59 |
| Species | Human |
| Gene ID | 25999 |
| Uniprot | Q96DZ5, |
| Species.1 | Mouse |
| Gene ID.1 | 76686 |
| Uniprot.1 | B9EHT4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor . Cytoplasm . Golgi apparatus, Golgi stack . Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae. |
| Tissue Expression | Brain,Skin,Uterus, |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD).,Function:Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics.,miscellaneous:The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required.,similarity:Contains 2 CAP-Gly domains.,similarity:Contains 3 ANK repeats.,subcellular location:Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.,subunit:Homodimer., |
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