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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Coronin 1A Polyclonal Antibody
SKU: WP11759 Categories: ,

Coronin 1A Polyclonal Antibody

Ucallm_WP11759-50

Price range: $268.00 through $328.00

SKU: WP11759-100
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Product details

Background:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010],

Specifications

Size50μL/100μL
TargetCoronin 1A
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)51kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from Coronin 1A . at AA range: 150-230
SpecificityCoronin 1A Polyclonal Antibody detects endogenous levels of Coronin 1A protein.
Gene NameCORO1A
Protein NameCoronin-1A
Other NameCORO1A; / CORO1; / Coronin-1A; / Coronin-like protein A; / Clipin-A; / Coronin-like protein p57; / Tryptophan aspartate-containing coat protein; / TACO
SpeciesHuman
Gene ID11151
UniprotP31146,
Species.1Mouse
Gene ID.112721
Uniprot.1O89053,
Species.2Rat
Gene ID.2155151
Uniprot.2Q91ZN1
Cellular LocalizationCytoplasm, cytoskeleton . Cytoplasm, cell cortex . Cytoplasmic vesicle, phagosome membrane . In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). .
Tissue ExpressionExpressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Phagosome
Research Areas>>Phagosome; / >>Tuberculosis
FunctionFunction:May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.,similarity:Belongs to the WD repeat coronin family.,similarity:Contains 5 WD repeats.,subcellular location:In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.,subunit:Binds actin.,tissue specificity:Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.,
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