Price range: $268.00 through $328.00
Background:
Stathmin is a widely existing cytoplasmic phosphoprotein, which can transfer and integrate signals in the cell environment. It can promote the depolymerization of microtubules and avoid the polymerization of microtubules. Stathmin is a specific marker to distinguish low-grade and high-grade cervical intraepithelial neoplasia. Its expression is related to the sensitivity of lung cancer and leukemia to chemotherapeutic drugs.
| Size | 50μL/100μL |
| Target | Stathmin 1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 17kD |
| MW(Observed) | 17kD |
| Host Species | Mouse |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM347 |
| Immunogen | Synthesized peptide derived from human Stathmin AA range: 1-100 |
| Specificity | The antibody can specifically recognize human Stathmin protein. In western blotting of Hela cell lysate, the antibody can label a 17 kDa band corresponding to Stathmin. |
| Gene Name | STMN1 C1orf215 LAP18 OP18 |
| Protein Name | C1orf215; Lag; LAP 18; LAP18; Leukemia associated phosphoprotein p18; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; OP 18; Op18; p18; p19; Phosphoprotein 19; Phosphoprotein p19; pp17; pp19; PR22; Pr22 protein; Prosolin; Protein Pr22; SMN; Stathmin; Stathmin1; STMN 1; Stmn1; STMN1_HUMAN |
| Other Name | C1orf215; / Lag; / LAP 18; / LAP18; / Leukemia associated phosphoprotein p18; / Leukemia-associated phosphoprotein p18; / Metablastin; / Oncoprotein 18; / OP 18; / Op18; / p18; / p19; / Phosphoprotein 19; / Phosphoprotein p19; / pp17; / pp19; / PR22; / Pr22 protein; / Prosolin; / Protein Pr22; / SMN; / Stathmin; / Stathmin1; / STMN 1; / Stmn1; / STMN1_HUMAN |
| Species | Human |
| Gene ID | 3925 |
| Uniprot | P16949, |
| Species.1 | Mouse |
| Gene ID.1 | 16765 |
| Uniprot.1 | P54227, |
| Species.2 | Rat |
| Gene ID.2 | 29332 |
| Uniprot.2 | P13668 |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Tonsil |
| Signaling_pathway | Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>MicroRNAs in cancer |
| Function | Disease:Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.,Function:Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.,PTM:Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.,similarity:Belongs to the stathmin family.,subunit:Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.,tissue specificity:Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver., |
