COX IV Monoclonal Antibody [6C8], HRP Conjugated
Ucallm_WM0777-50
Price range: $268.00 through $328.00
Product details
Background:
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes
Specifications
| Size | 50μL/100μL |
| Target | COX IV |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF |
| MW(Calculated) | 20kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG1 |
| Conjugate/Modification | HRP |
| Recommended Dilution Ratio | Optimal working dilutions should be determined experimentally by the investigator; Suggested starting dilutions are as follows:WB 1:1000-3000; IHC 1:50-300. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Concentration | 1mg/ml |
| Clonality | Monoclonal |
| Clone Number | 6C8 |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | COX IV Monoclonal Antibody(6C8) HRP Conjugated, specially designed for your Western blot analysis. |
| Gene Name | COX4I1 |
| Protein Name | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
| Other Name | COX4I1 |
| Species | Human |
| Gene ID | 1327 |
| Uniprot | P13073 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion inner membrane; Single-pass membrane protein . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Oxidative phosphorylation; / >>Metabolic pathways; / >>Cardiac muscle contraction; / >>Thermogenesis; / >>Non-alcoholic fatty liver disease; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Chemical carcinogenesis - reactive oxygen species; / >>Diabetic cardiomyopathy |
| Function | Function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase IV family.,tissue specificity:Ubiquitous., |
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