COX5b Polyclonal Antibody
Ucallm_WP11772-50
Price range: $268.00 through $328.00
Product details
Background:
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | COX5b |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 14kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; WB 1:1000-1:5000; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human COX5B. AA range:11-60 |
| Specificity | COX5b Polyclonal Antibody detects endogenous levels of COX5b protein. |
| Gene Name | COX5B |
| Protein Name | Cytochrome c oxidase subunit 5B mitochondrial |
| Other Name | COX5B; / Cytochrome c oxidase subunit 5B; / mitochondrial; / Cytochrome c oxidase polypeptide Vb |
| Species | Human |
| Gene ID | 1329 |
| Uniprot | P10606, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P19536, |
| Species.2 | Rat |
| Gene ID.2 | 94194 |
| Uniprot.2 | P12075 |
| Cellular Localization | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side . |
| Tissue Expression | Liver,Skin, |
| Signaling_pathway | Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Oxidative phosphorylation; / >>Metabolic pathways; / >>Cardiac muscle contraction; / >>Thermogenesis; / >>Non-alcoholic fatty liver disease; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Chemical carcinogenesis - reactive oxygen species; / >>Diabetic cardiomyopathy |
| Function | Function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase subunit 5B family., |
Please login to post questions
Related products
