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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/CREM Polyclonal Antibody
SKU: WP11796 Categories: ,

CREM Polyclonal Antibody

Ucallm_WP11796-50

Price range: $268.00 through $328.00

SKU: WP11796-100
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Product details

Background:

cAMP responsive element modulator(CREM) Homo sapiens This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCREM
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)34kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CREM. AA range:81-130
SpecificityCREM Polyclonal Antibody detects endogenous levels of CREM protein.
Gene NameCREM
Protein NamecAMP-responsive element modulator
Other NameCREM; / cAMP-responsive element modulator; / Inducible cAMP early repressor; / ICER
SpeciesHuman
Gene ID1390
UniprotQ03060,
Species.1Mouse
Gene ID.112916
Uniprot.1P27699,
Species.2Rat
Gene ID.225620
Uniprot.2Q03061
Cellular LocalizationNucleus.; [Isoform 6]: Cytoplasm . Nucleus .
Tissue ExpressionExpressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Signaling_pathwayOrganismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes
Research Areas>>Adrenergic signaling in cardiomyocytes
FunctionCaution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Function:Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.,PTM:Stimulated by phosphorylation.,sequence Caution:Translated as Tyr.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 KID (kinase-inducible) domain.,subunit:Binds DNA as a dimer. Interacts with FHL5.,tissue specificity:Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.,
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