CRF Polyclonal Antibody
Ucallm_WP11797-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation a
Specifications
| Size | 50μL/100μL |
| Target | CRH |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 21kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CRF. AA range:104-153 |
| Specificity | CRF Polyclonal Antibody detects endogenous levels of CRF protein. |
| Gene Name | CRH |
| Protein Name | Corticoliberin |
| Other Name | CRH; / Corticoliberin; / Corticotropin-releasing factor; / CRF; / Corticotropin-releasing hormone |
| Species | Human |
| Gene ID | 1392 |
| Uniprot | P06850, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8CIT0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . |
| Tissue Expression | Produced by the hypothalamus and placenta. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Long-term depression; / >>Cushing syndrome; / >>Alcoholism |
| Function | Function:This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.,online information:Corticotropin-releasing hormone entry,similarity:Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family., |
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