CRMP-2 Polyclonal Antibody
Ucallm_WP11802-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],
Specifications
| Size | 50μL/100μL |
| Target | CRMP-2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 62kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DRP-2. AA range:480-529 |
| Specificity | CRMP-2 Polyclonal Antibody detects endogenous levels of CRMP-2 protein. |
| Gene Name | DPYSL2 |
| Protein Name | Dihydropyrimidinase-related protein 2 |
| Other Name | DPYSL2; / CRMP2; / ULIP2; / Dihydropyrimidinase-related protein 2; / DRP-2; / Collapsin response mediator protein 2; / CRMP-2; / N2A3; / Unc-33-like phosphoprotein 2; / ULIP-2 |
| Species | Human |
| Gene ID | 1808 |
| Uniprot | Q16555, |
| Species.1 | Mouse |
| Gene ID.1 | 12934 |
| Uniprot.1 | O08553, |
| Species.2 | Rat |
| Gene ID.2 | 25416 |
| Uniprot.2 | P47942 |
| Cellular Localization | Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Membrane . Tightly but non-covalently associated with membranes. |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | >>Axon guidance |
| Function | Function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4.,tissue specificity:Ubiquitous., |
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