CROT Polyclonal Antibody
Ucallm_WP11804-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4, 8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009],
Specifications
| Size | 50μL/100μL |
| Target | CROT |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 72kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from CROT . at AA range: 190-270 |
| Specificity | CROT Polyclonal Antibody detects endogenous levels of CROT protein. |
| Gene Name | CROT |
| Protein Name | Peroxisomal carnitine O-octanoyltransferase |
| Other Name | CROT; / COT; / Peroxisomal carnitine O-octanoyltransferase; / COT |
| Species | Human |
| Gene ID | 54677 |
| Uniprot | Q9UKG9, |
| Species.1 | Mouse |
| Gene ID.1 | 74114 |
| Uniprot.1 | Q9DC50, |
| Species.2 | Rat |
| Gene ID.2 | 83842 |
| Uniprot.2 | P11466 |
| Cellular Localization | Peroxisome . |
| Tissue Expression | Brain,Skin, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Peroxisome |
| Research Areas | >>Peroxisome |
| Function | Catalytic activity:Octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine.,Function:Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.,pathway:Lipid metabolism; fatty acid beta-oxidation.,similarity:Belongs to the carnitine/choline acetyltransferase family.,subunit:Monomer., |
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