CstF-64 Polyclonal Antibody
Ucallm_WP11825-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CstF-64 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CSTF2. AA range:11-60 |
| Specificity | CstF-64 Polyclonal Antibody detects endogenous levels of CstF-64 protein. |
| Gene Name | CSTF2 |
| Protein Name | Cleavage stimulation factor subunit 2 |
| Other Name | CSTF2; / Cleavage stimulation factor subunit 2; / CF-1 64 kDa subunit; / Cleavage stimulation factor 64 kDa subunit; / CSTF 64 kDa subunit; / CstF-64 |
| Species | Human |
| Gene ID | 1478 |
| Uniprot | P33240, |
| Species.1 | Mouse |
| Gene ID.1 | 108062 |
| Uniprot.1 | Q8BIQ5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Localized with DDX1 in cleavage bodies. |
| Tissue Expression | Kidney,Ovary, |
| Signaling_pathway | |
| Research Areas | >>mRNA surveillance pathway |
| Function | Function:One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs.,induction:Up-regulated during the G0 to S phase transition.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells. Interacts with FIP1L1., |
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