Price range: $268.00 through $328.00
Background:The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009],
| Size | 50μL/100μL |
| Target | CTGF |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IP, IF, ELISA |
| MW(Calculated) | 38kD |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000; IP 1:50-200; IF 1:200-1:1000; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0191R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | CTGF CCN2 HCS24 IGFBP8 |
| Protein Name | Connective tissue growth factor (CCN family member 2) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8) |
| Other Name | CTGF; / CCN2; / HCS24; / IGFBP8; / Connective tissue growth factor; / CCN family member 2; / Hypertrophic chondrocyte-specific protein 24; / Insulin-like growth factor-binding protein 8; / IBP-8; / IGF-binding protein 8; / IGFBP-8 |
| Species | Human |
| Gene ID | 1490 |
| Uniprot | P29279, |
| Species.1 | Mouse |
| Gene ID.1 | 14219 |
| Uniprot.1 | P29268, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9R1E9 |
| Cellular Localization | Secreted |
| Tissue Expression | Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway |
| Research Areas | >>Apelin signaling pathway; / >>Hippo signaling pathway |
| Function | Function:Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Monomer., |
