Cyclophilin B Monoclonal Antibody [2B10], Cy5 Conjugated
Ucallm_WM0787-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009],
Specifications
| Size | 50μL/100μL |
| Target | Cyclophilin B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG |
| Conjugate/Modification | Cy5 |
| Recommended Dilution Ratio | Optimal working dilutions should be determined experimentally by the investigator; Suggested starting dilutions are as follows:IHC 1:50-300; IF 1:50-200. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in dark. |
| Concentration | 1mg/ml |
| Clonality | Monoclonal |
| Clone Number | 2B10 |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Cyclophilin B Monoclonal Antibody(2B10) Cy5 Conjugated specially designed for your Immunofluorescence analysis. |
| Gene Name | PPIB |
| Protein Name | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) |
| Other Name | Cyclophilin B |
| Species | Human |
| Gene ID | 5479 |
| Uniprot | P23284 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Virion . (Microbial infection).; Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). . |
| Tissue Expression | Brain,Fetal brain cortex,Prostate,Skin, |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,Caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., |
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