CYP2J2 Polyclonal Antibody
Ucallm_WP11891-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016],
Specifications
| Size | 50μL/100μL |
| Target | CYP2J2 |
| Reactivity | Human, Monkey |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 58kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2J2. AA range:231-280 |
| Specificity | CYP2J2 Polyclonal Antibody detects endogenous levels of CYP2J2 protein. |
| Gene Name | CYP2J2 |
| Protein Name | Cytochrome P450 2J2 |
| Other Name | CYP2J2; / Cytochrome P450 2J2; / Arachidonic acid epoxygenase; / CYPIIJ2 |
| Species | Human |
| Gene ID | 1573 |
| Uniprot | P51589 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Tissue Expression | Highly expressed in heart, present at lower levels in liver, kidney and skeletal muscle (at protein level). |
| Signaling_pathway | Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels |
| Research Areas | >>Arachidonic acid metabolism; / >>Linoleic acid metabolism; / >>Metabolic pathways; / >>Serotonergic synapse; / >>Inflammatory mediator regulation of TRP channels; / >>Ovarian steroidogenesis; / >>Lipid and atherosclerosis |
| Function | Catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,Function:This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.,online information:CYP2J2 alleles,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney., |
Please login to post questions
Related products
