CYP39A1 Polyclonal Antibody
Ucallm_WP11897-50
Price range: $268.00 through $328.00
Product details
Background:
cytochrome P450 family 39 subfamily A member 1(CYP39A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Specifications
| Size | 50μL/100μL |
| Target | CYP39A1 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from the Internal region of human CYP39A1. |
| Specificity | CYP39A1 Polyclonal Antibody detects endogenous levels of CYP39A1 protein. |
| Gene Name | CYP39A1 |
| Protein Name | 24-hydroxycholesterol 7-alpha-hydroxylase |
| Other Name | CYP39A1; / 24-hydroxycholesterol 7-alpha-hydroxylase; / Cytochrome P450 39A1; / hCYP39A1; / Oxysterol 7-alpha-hydroxylase |
| Species | Human |
| Gene ID | 51302 |
| Uniprot | Q9NYL5, |
| Species.1 | Mouse |
| Gene ID.1 | 56050 |
| Uniprot.1 | Q9JKJ9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein . Microsome membrane; Multi-pass membrane protein . |
| Tissue Expression | Liver specific. |
| Signaling_pathway | |
| Research Areas | >>Primary bile acid biosynthesis |
| Function | Catalytic activity:(24R)-cholest-5-ene-3-beta,24-diol + NADPH + O(2) = (24R)-cholest-5-ene-3-beta,7-alpha,24-triol + NADP(+) + H(2)O.,cofactor:Heme group.,Function:Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Liver specific., |
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