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Cystatin A Polyclonal Antibody
Ucallm_WP11919-50
Price range: $268.00 through $328.00
Product details
Background:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Cystatin A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 11kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Stefin A. AA range:49-98 |
| Specificity | Cystatin A Polyclonal Antibody detects endogenous levels of Cystatin A protein. |
| Gene Name | CSTA |
| Protein Name | Cystatin-A |
| Other Name | CSTA; / STF1; / STFA; / Cystatin-A; / Cystatin-AS; / Stefin-A |
| Species | Human |
| Gene ID | 1475 |
| Uniprot | P01040, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P56567 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Expressed in the skin throughout the epidermis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:This is an intracellular thiol proteinase inhibitor.,similarity:Belongs to the cystatin family., |
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