Name: Cytokeratin 8&18 [ABT053/CK18] mouse mAb
SKU: WM1402
Price: 268 USD
Availability: InStock

Cytokeratin 8&18 [ABT053/CK18] mouse mAb

Ucallm_WM1402-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WM1402-50

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Product details

Background:
Cytokeratin 18 (CK18), an intermediated filament protein with a molecular weight of 45 KD, belongs to type I cytokeratin family. Cytokeratin 8 (CK8) is an intermediated filament protein with a molecular weight of 52 KD. It is a member of cytokeratin type II family. They are widely expressed in monolayer epithelial cells of thyroid, breast, gastrointestinal tract and respiratory tract. Ck8/18 is often used as a useful marker to identify adenocarcinoma from simple epithelial cells.

Specifications

Size	50μL/100μL
Target	Cytokeratin 8/18
Reactivity	Human, Mouse, Rat
Applications	IHC, WB, IF, ELISA
MW(Calculated)
MW(Observed)	48,54kD
Host Species	Mouse
Isotype	IgG2b,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM053/CK18
Immunogen	Synthesized peptide derived from human Cytokeratin 8&18 AA range: C-term to CK8 and 200-300 to CK18
Specificity	This product can specifically recognize human CK8 and CK18 protein. It is a cocktail of anti-CK8 and anti-CK18 monoclonal antibodies.
Gene Name	KRT8/KRT18
Protein Name
Other Name	CARD2; / CK 8; / CK-8; / CK8; / CYK8; / CYKER; / Cytokeratin endo A; / CytokeRatin-8; / DreK8; / EndoA; / K2C8; / K2C8_HUMAN; / K8; / KeRatin 8; / KeRatin type II cytoskeletal 8; / KeRatin, type II cytoskeletal 8; / KeRatin-8; / KO; / Krt 2.8; / KRT8; / MGC118110; / MGC174782; / MGC53564; / MGC85764; / sb:cb186; / Type-II keRatin Kb8; / CK 18; / CK-18; / CK18; / CYK18; / Cytokeratin 18; / Cytokeratin endo B; / CytokeRatin-18; / K 18; / K18; / K1C18_HUMAN; / KA18; / KeRatin 18; / KeRatin 18, type I; / KeRatin D; / keRatin, type I cytoskeletal 18; / KeRatin-18; / Krt18
Species	Human
Gene ID	3856;3875
Uniprot	P05787;P05783
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasmic, Membranous
Tissue Expression	Liver/ Tonsil
Signaling_pathway	Organismal Systems >> Endocrine system >> Estrogen signaling pathway
Research Areas
Function	Disease:Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].,Function:Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.,tissue specificity:Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.,

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Cytokeratin 8&18 [ABT053/CK18] mouse mAb

Product details

Specifications

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Cytokeratin 8&18 [ABT053/CK18] mouse mAb

Product details

Specifications

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