Dectin-2 Polyclonal Antibody
Ucallm_WP15677-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
Specifications
| Size | 50μL/100μL |
| Target | Dectin-2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 23kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from the Internal region of human Dectin-2. |
| Specificity | Dectin-2 Polyclonal Antibody detects endogenous levels of Dectin-2 protein. |
| Gene Name | CLEC6A |
| Protein Name | C-type lectin domain family 6 member A |
| Other Name | CLEC6A; / CLECSF10; / DECTIN2; / C-type lectin domain family 6 member A; / C-type lectin superfamily member 10; / Dendritic cell-associated C-type lectin 2; / DC-associated C-type lectin 2; / Dectin-2 |
| Species | Human |
| Gene ID | 93978 |
| Uniprot | Q6EIG7, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JKF4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein . |
| Tissue Expression | Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids. |
| Signaling_pathway | |
| Research Areas | >>C-type lectin receptor signaling pathway |
| Function | Function:May be involved in regulating immune reactivity.,similarity:Contains 1 C-type lectin domain.,tissue specificity:Expressed in dendritic cells., |
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