Product details
Background:
DMAP1 rabbit pAb
Ucallm_WP6359-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DMAP1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 51kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DMAP1 |
| Specificity | This antibody detects endogenous levels of DMAP1 at Human, Mouse |
| Gene Name | DMAP1 KIAA1425 |
| Protein Name | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) |
| Other Name | |
| Species | Human |
| Gene ID | 55929 |
| Uniprot | Q9NPF5, |
| Species.1 | Mouse |
| Gene ID.1 | 66233 |
| Uniprot.1 | Q9JI44 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Cytoplasm. Targeted to replication foci throughout S phase by DNMT1. |
| Tissue Expression | |
| Signaling_pathway | Genetic Information Processing >> Chromosome >> ATP-dependent chromatin remodeling |
| Research Areas | |
| Function | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. |
Please login to post questions
Related products
