SKU: WP12023 Categories: ,

Dmc1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12023-100
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Product details

Background:

DNA meiotic recombinase 1(DMC1) Homo sapiens This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013],

Specifications

Size50μL/100μL
TargetDmc1
ReactivityHuman, Mouse
ApplicationsIHC, IF, ELISA
MW(Calculated)38kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human DMC1. AA range:61-110
SpecificityDmc1 Polyclonal Antibody detects endogenous levels of Dmc1 protein.
Gene NameDMC1
Protein NameMeiotic recombination protein DMC1/LIM15 homolog
Other NameDMC1; / DMC1H; / LIM15; / Meiotic recombination protein DMC1/LIM15 homolog
SpeciesHuman
Gene ID11144
UniprotQ14565,
Species.1Mouse
Gene ID.113404
Uniprot.1Q61880
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Chromosome .
Tissue ExpressionOvary,Testis,Thymus,
Signaling_pathway
Research Areas
FunctionFunction:May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.,similarity:Belongs to the recA family. DMC1 subfamily.,similarity:Contains 1 HhH domain.,subunit:Interacts with the MND1-PSMC3IP heterodimer (By similarity). Double stacked ring-shaped homooctamer.,
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