Product details
Background:
DNAJB12 rabbit pAb
Ucallm_WP6345-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DNAJB12 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 41kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DNAJB12 |
| Specificity | This antibody detects endogenous levels of DNAJB12 at Human, Mouse |
| Gene Name | DNAJB12 |
| Protein Name | DnaJ homolog subfamily B member 12 |
| Other Name | |
| Species | Human |
| Gene ID | 54788 |
| Uniprot | Q9NXW2, |
| Species.1 | Mouse |
| Gene ID.1 | 56709 |
| Uniprot.1 | Q9QYI4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass membrane protein . Nucleus membrane; Single-pass membrane protein . Localizes to the endoplasmic reticulum membrane (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661). When overexpressed, forms membranous structures in the nucleus (PubMed:24732912). . |
| Tissue Expression | |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | |
| Function | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway . Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities . Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers . While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 . When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear .; (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection . |
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