Price range: $268.00 through $328.00
Background:
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011],
| Size | 50μL/100μL |
| Target | DNJB2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 35kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 260-340 |
| Specificity | DNJB2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | DNAJB2 HSJ1 HSPF3 |
| Protein Name | DnaJ homolog subfamily B member 2 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) |
| Other Name | |
| Species | Human |
| Gene ID | 3300 |
| Uniprot | P25686, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9QYI5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 2]: Cytoplasm . Nucleus .; [Isoform 1]: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side . |
| Tissue Expression | More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:1599432, PubMed:12754272). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272). |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | >>Protein processing in endoplasmic reticulum |
| Function | Alternative products:Experimental confirmation may be lacking for some isoforms,similarity:Contains 1 J domain.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,tissue specificity:Brain (neuronal layers). Weakly, in skeletal muscle and spleen., |
