Name: Dok-5 Polyclonal Antibody
SKU: WP12054
Price: 268 USD
Availability: InStock

Dok-5 Polyclonal Antibody

Ucallm_WP12054-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12054-100

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Product details

Background:

docking protein 5(DOK5) Homo sapiens The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014],

Specifications

Size	50μL/100μL
Target	Dok-5
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	36kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human DOK5. AA range:101-150
Specificity	Dok-5 Polyclonal Antibody detects endogenous levels of Dok-5 protein.
Gene Name	DOK5
Protein Name	Docking protein 5
Other Name	DOK5; / C20orf180; / Docking protein 5; / Downstream of tyrosine kinase 5; / Insulin receptor substrate 6; / IRS-6; / IRS6
Species	Human
Gene ID	55816
Uniprot	Q9P104,
Species.1	Mouse
Gene ID.1	76829
Uniprot.1	Q91ZM9
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	intracellular,
Tissue Expression	Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Signaling_pathway
Research Areas
Function	Domain:PTB domain mediates receptor interaction.,Function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.,PTM:Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.,similarity:Belongs to the DOK family. Type B subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP.,tissue specificity:Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.,