DR5 mouse mAb
Ucallm_WM0674-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009],
Specifications
| Size | 50μL/100μL |
| Target | DR5 |
| Reactivity | Human, Mouse |
| Applications | WB, ICC |
| MW(Calculated) | |
| MW(Observed) | 48kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ICC 1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 19D4 |
| Immunogen | Purified recombinant human DR5 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of DR5 and does not cross-react with related proteins. |
| Gene Name | TNFRSF10B DR5 KILLER TRAILR2 TRICK2 ZTNFR9 UNQ160/PRO186 |
| Protein Name | Tumor necrosis factor receptor superfamily member 10B |
| Other Name | Fas like protein; / Apoptosis inducing protein TRICK2A/2B; / Apoptosis inducing receptor TRAIL R2; / CD 262; / CD262; / CD262 antigen; / Cytotoxic TRAIL receptor 2; / Death domain containing receptor for TRAIL/Apo 2L; / Death domain containing receptor for TRAIL/Apo2L; / Death receptor 5; / DR 5; / DR5; / Fas like protein precursor; / KILLER; / KILLER/DR5; / OTTHUMP00000123492; / OTTHUMP00000123493; / p53 regulated DNA damage inducible cell death receptor; / killer; / p53 regulated DNA damage inducible cell death receptor; / killer; / TNF related apoptosis inducing ligand receptor 2; / TNF related apoptosis inducing ligand receptor 2; / TNF-related apoptosis-inducing ligand receptor 2; / TNFRSF10B; / TR10B_HUMAN; / TRAIL R2; / TRAIL receptor 2; / TRAIL-R2; / TRAILR2; / TRANCER; / TRICK2; / TRICK2A; / TRICK2B; / TRICKB; / Tumor necrosis factor receptor like protein ZTNFR9; / Tumor necrosis factor receptor like protein ZTNFR9; / Tumor necrosis factor receptor superfamily member 10b; / Tumor necrosis factor receptor superfamily, member 10b; / ZTNFR9. |
| Species | Human |
| Gene ID | 8795 |
| Uniprot | O14763, |
| Species.1 | Mouse |
| Gene ID.1 | 21933 |
| Uniprot.1 | Q9QZM4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Apoptosis;Cellular Processes >> Cell growth and death >> Necroptosis;Cellular Processes >> Cell growth and death >> p53 signaling pathway;Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>p53 signaling pathway; / >>Apoptosis; / >>Necroptosis; / >>Natural killer cell mediated cytotoxicity; / >>Pathogenic Escherichia coli infection; / >>Salmonella infection; / >>Influenza A; / >>Lipid and atherosclerosis |
| Function | Disease:Defects in TNFRSF10B may be a cause of squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355].,Function:Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.,induction:TNFRSF10B is regulated by the tumor suppressor p53.,similarity:Contains 1 death domain.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Homotrimer. Can interact with TRADD and RIP.,tissue specificity:Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 and G361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain., |
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