DST rabbit pAb
Ucallm_WP7769-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | DST |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 833kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DST |
| Specificity | This antibody detects endogenous levels of DST at Human, Mouse |
| Gene Name | DST BP230 BP240 BPAG1 DMH DT KIAA0728 |
| Protein Name | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) |
| Other Name | |
| Species | Human |
| Gene ID | 667 |
| Uniprot | Q03001, |
| Species.1 | Mouse |
| Gene ID.1 | 13518 |
| Uniprot.1 | Q91ZU6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, stress fiber . Cell projection, axon . Associates with intermediate filaments, actin and microtubule cytoskeletons. Localizes to actin stress fibers and to actin-rich ruffling at the cortex of cells (By similarity). Associated at the growing distal tip of microtubules. .; [Isoform 1]: Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere, H zone . Localizes to microtubules and actin microfilaments throughout the cytoplasm and at focal contact attachments at the plasma membrane. .; [Isoform 2]: Cytoplasm, cytoskeleton . Colocalizes both cortical and cytoplasmic actin filaments. .; [Isoform 3]: Cytoplasm, cytoskeleton. Cell junction, hemidesmosome. Localizes to actin and intermediate filaments cytoskeletons (By similarity). Colocalizes with the epidermal KRT5-KRT14 intermediate filaments network of keratins. Colocalizes with ITGB4 at the leading edge of migrating keratinocytes. .; [Isoform 6]: Nucleus . Nucleus envelope . Membrane; Single-pass membrane protein . Endoplasmic reticulum membrane; Single-pass membrane protein . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, stress fiber . Localizes to actin and intermediate filaments cytoskeletons. Localizes to central actin stress fibers around the nucleus and is excluded form focal contact sites in myoblast cells. Translocates to the nucleus (By similarity). Associates with actin cytoskeleton in sensory neurons. .; [Isoform 7]: Cytoplasm, cytoskeleton . Cell projection, axon . Membrane . Associates with axonal microtubules and intermediate filaments, but not with actin cytoskeleton, in sensory neurons.; [Isoform 8]: Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Cell membrane; Lipid-anchor . |
| Tissue Expression | Isoform 1 is expressed in myoblasts (at protein level). Isoform 3 is expressed in the skin. Isoform 6 is expressed in the brain. Highly expressed in skeletal muscle and cultured keratinocytes. |
| Signaling_pathway | |
| Research Areas | |
| Function | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity).; [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; [Isoform 6]: Required for bundling actin filaments around the nucleus.; [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
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