DUOX1 rabbit pAb
Ucallm_WP16749-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012],
Specifications
| Size | 50μL/100μL |
| Target | DUOX1 |
| Reactivity | Human, Rat |
| Applications | WB |
| MW(Calculated) | 171kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DUOX1 AA range: 1398-1448 |
| Specificity | This antibody detects endogenous levels of DUOX1 at Human/Rat |
| Gene Name | DUOX1 DUOX LNOX1 THOX1 |
| Protein Name | DUOX1 |
| Other Name | |
| Species | Human |
| Gene ID | 53905 |
| Uniprot | Q9NRD9, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 266807 |
| Uniprot.2 | Q8CIY2 |
| Cellular Localization | Apical cell membrane; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells. |
| Tissue Expression | Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. |
| Signaling_pathway | |
| Research Areas | >>Thyroid hormone synthesis |
| Function | Catalytic activity:NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).,developmental stage:Widely expressed in fetal tissues.,enzyme regulation:The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.,Function:Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.,induction:By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.,pathway:Hormone biosynthesis; thyroid hormone biosynthesis.,PTM:N-glycosylated.,sequence Caution:Translated as Arg.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,similarity:Contains 3 EF-hand domains.,similarity:In the N-terminal section; belongs to the peroxidase family.,subcellular location:Localizes to the apical membrane of epithelial cells.,subunit:Interacts with TXNDC11, TPO and CYBA.,tissue specificity:Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart., |
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