Dynamin I Monoclonal Antibody
Ucallm_WM0146-50
Price range: $268.00 through $328.00
Product details
Background:
dynamin 1(DNM1) Homo sapiens This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Dynamin I |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 97kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 18C8 |
| Immunogen | Purified recombinant fragment of human Dynamin I expressed in E. Coli. |
| Specificity | Dynamin I Monoclonal Antibody detects endogenous levels of Dynamin I protein. |
| Gene Name | DNM1 |
| Protein Name | Dynamin-1 |
| Other Name | DNM1; / DNM; / Dynamin-1 |
| Species | Human |
| Gene ID | 1759 |
| Uniprot | Q05193, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P39053 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated. |
| Tissue Expression | Brain,Platelet,PNS, |
| Signaling_pathway | Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway |
| Research Areas | >>Phospholipase D signaling pathway; / >>Endocytosis; / >>Synaptic vesicle cycle; / >>Endocrine and other factor-regulated calcium reabsorption; / >>Bacterial invasion of epithelial cells |
| Function | Catalytic activity:GTP + H(2)O = GDP + phosphate.,Function:Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,similarity:Contains 1 PH domain.,subcellular location:Microtubule-associated.,subunit:Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3., |
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