Price range: $268.00 through $328.00
Background:
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011],
| Size | 50μL/100μL |
| Target | Dynein LC 1 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DNAL1. AA range:121-170 |
| Specificity | Dynein LC 1 Polyclonal Antibody detects endogenous levels of Dynein LC 1 protein. |
| Gene Name | DNAL1 |
| Protein Name | Dynein light chain 1 axonemal |
| Other Name | DNAL1; / C14orf168; / Dynein light chain 1; / axonemal |
| Species | Human |
| Gene ID | 83544 |
| Uniprot | Q4LDG9, |
| Species.1 | Mouse |
| Gene ID.1 | 105000 |
| Uniprot.1 | Q05A62 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton, cilium axoneme . |
| Tissue Expression | Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis. |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Pathways of neurodegeneration - multiple diseases |
| Function | similarity:Belongs to the dynein light chain LC1-type family.,similarity:Contains 4 LRR (leucine-rich) repeats.,subunit:Interacts with DNAH5.,tissue specificity:Expressed in tissues carrying motile cilia such as testis., |
