EAAT2 Polyclonal Antibody
Ucallm_WP5880-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],
Specifications
| Size | 50μL/100μL |
| Target | EAAT2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 62kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic Peptide of EAAT2 AA range: 370-420 |
| Specificity | EAAT2 protein(A223) detects endogenous levels of EAAT2 |
| Gene Name | SLC1A2 EAAT2 GLT1 |
| Protein Name | Excitatory amino acid transporter 2 |
| Other Name | Excitatory amino acid transporter 2; / Glutamate/aspartate transporter II; / Sodium-dependent glutamate/aspartate transporter 2; / Solute carrier family 1 member 2 |
| Species | Human |
| Gene ID | 6506 |
| Uniprot | P43004, |
| Species.1 | Mouse |
| Gene ID.1 | 20511 |
| Uniprot.1 | P43006, |
| Species.2 | Rat |
| Gene ID.2 | 29482 |
| Uniprot.2 | P31596 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Brain,Brain cortex,Pancreas, |
| Signaling_pathway | Organismal Systems >> Nervous system >> Glutamatergic synapse;Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease |
| Research Areas | >>Synaptic vesicle cycle; / >>Glutamatergic synapse; / >>Amyotrophic lateral sclerosis; / >>Huntington disease |
| Function | Function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.,PTM:Glycosylated.,similarity:Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family.,subunit:Homotrimer. Interacts with JUB., |
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