Price range: $268.00 through $328.00
Background:
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | EAT-2 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 15kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SH2D1B. AA range:71-120 |
| Specificity | EAT-2 Polyclonal Antibody detects endogenous levels of EAT-2 protein. |
| Gene Name | SH2D1B |
| Protein Name | SH2 domain-containing protein 1B |
| Other Name | SH2D1B; / EAT2; / SH2 domain-containing protein 1B; / EWS/FLI1-activated transcript 2; / EAT-2 |
| Species | Human |
| Gene ID | 117157 |
| Uniprot | O14796, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O35324 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | intracellular,cytosol, |
| Tissue Expression | Leukocyte,Lung,Spleen, |
| Signaling_pathway | Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity |
| Research Areas | >>Natural killer cell mediated cytotoxicity |
| Function | Function:Plays a role in controlling signal transduction through at least four receptors, CD84, CD150, CD229 and CD244, expressed on the surface of professional antigen-presenting cells.,similarity:Contains 1 SH2 domain.,subunit:Binds to the phosphorylated receptors CD84, CD150, CD229 and CD244. Does not bind to non-phosphorylated CD150., |
