Price range: $268.00 through $328.00
Background:
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | EF-Tu |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TUFM. AA range:301-350 |
| Specificity | EF-Tu Polyclonal Antibody detects endogenous levels of EF-Tu protein. |
| Gene Name | TUFM |
| Protein Name | Elongation factor Tu mitochondrial |
| Other Name | TUFM; / Elongation factor Tu; / mitochondrial; / EF-Tu; / P43 |
| Species | Human |
| Gene ID | 7284 |
| Uniprot | P49411, |
| Species.1 | Mouse |
| Gene ID.1 | 233870 |
| Uniprot.1 | Q8BFR5, |
| Species.2 | Rat |
| Gene ID.2 | 293481 |
| Uniprot.2 | P85834 |
| Cellular Localization | Mitochondrion . |
| Tissue Expression | Brain,Cajal-Retzius cell,Heart,Kidney,Liver,Lung,Placenta,P |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in TUFM are the cause of combined oxidative phosphorylation deficiency type 4 (COXPD4) [MIM:610678]. COXPD4 is characterized by neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes.,Function:This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.,similarity:Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily., |
