eIF2β Polyclonal Antibody
Ucallm_WP12140-50
Price range: $268.00 through $328.00
Product details
Background:
eukaryotic translation initiation factor 2 subunit beta(EIF2S2) Homo sapiens Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
Specifications
| Size | 50μL/100μL |
| Target | eIF2β |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from eIF2β . at AA range: 10-90 |
| Specificity | eIF2β Polyclonal Antibody detects endogenous levels of eIF2β protein. |
| Gene Name | EIF2S2 EIF2B |
| Protein Name | Eukaryotic translation initiation factor 2 subunit 2 |
| Other Name | EIF2S2; / EIF2B; / Eukaryotic translation initiation factor 2 subunit 2; / Eukaryotic translation initiation factor 2 subunit beta; / eIF-2-beta |
| Species | Human |
| Gene ID | 8894 |
| Uniprot | P20042, |
| Species.1 | Mouse |
| Gene ID.1 | 67204 |
| Uniprot.1 | Q99L45 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | nucleus,cytoplasm,cytosol,eukaryotic translation initiation factor 2 complex, |
| Tissue Expression | Amygdala,Brain,Epithelium,Lung,Muscle,Placenta,Pool |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.,similarity:Belongs to the eIF-2-beta/eIF-5 family.,subunit:Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5., |
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